Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Patients With Uncomplicated Plasmodium Falciparum Malaria

Inclusion Criteria:

1. Male and female patients ≥18 years of age for Part A and ≥12 years of age for Part B
at screening.

2. Patients must have acute uncomplicated P. falciparum malaria mono infection at
screening confirmed by a parasite count between 5,000 to 150,000 asexual parasite
count/μl of blood for P. falciparum for Part A and between 1,000 to 150,000 asexual
parasite count/μl of blood for Part B

3. Patients in Part A must weigh between 40 kg and 90 kg. Patients in Part B must weigh
between 35 kg and 90 kg at screening.

Exclusion Criteria:

1. Patients with signs and symptoms of severe/complicated malaria at screening or mixed
Plasmodium infection (i.e., infection with more than one malaria species) at
screening

2. Moderate to severe anemia, chronic hemoglobinopathy (Hemoglobin level < 8 g/dL), or
known chronic underlying disease such as sickle cell disease at screening

3. Known clinically significant liver disease (e.g., chronic hepatitis, liver cirrhosis
(compensated or decompensated), history of hepatitis B or C, hepatitis A or B
vaccination in the last 3 months, known gallbladder or bile duct disease, acute or
chronic pancreatitis. Clinical or laboratory evidence of any of the following at
screening:

- AST/ALT > 3 x the upper limit of normal range (ULN), regardless of the level of
total bilirubin

- AST/ALT > 1.5 and ≤ 2 x ULN and total bilirubin is > ULN

- Total bilirubin > 2 x ULN, regardless of the level of AST/ALT

4. Any known/suspected immunosuppressive or immunodeficient condition, including human
immunodeficiency virus (HIV) infection at screening.

5. Pregnant or nursing (lactating) women, women of child-bearing potential, defined as
all women physiologically capable of becoming pregnant, unless they are using
methods of effective contraception, and sexually active patients not willing to
practice effective contraception.

6. History or current diagnosis of ECG abnormalities indicating significant risk of
safety for patients participating in the study such as:

- Concomitant clinically significant cardiac arrhythmias, e.g., sustained
ventricular tachycardia, and clinically significant second or third degree AV
block without a pacemaker

- History of familial long QT syndrome or known family history of Torsades de
Pointe.

- Resting heart rate (physical exam or 12 lead ECG) < 60 bpm

Other protocol-defined inclusion/exclusion criteria may apply.